He graduated in architecture at the Politecnico in Milan; in 1948 he moved to Chicago, where he was "Visiting Professor" at the Design Institute of the Illinois Institute of Technology.
On his return to Italy, in 1965, he opened a professional studio in Milan with Bruno Morassutti, with whom he worked until 1970. He's one of the founders of ADI, Association for Industrial Design (1965).
In the field of architecture he distinguishes itself in research on materials and construction techniques, experimenting in particular the possibilities offered by prefabrication techniques and industrial production.
He joins the professional activity of teaching in Italy and abroad, holding courses and conferences in numerous Italian and foreign universities.
In 1989 he opened "studio Mangiarotti & Associates" in Tokyo, collaborating with ten Japanese architects. In 1990 he was "Visiting Professor" at the Politecnico di Milano. He outlined the theoretical foundations of his work in the volume "In nome dell’architettura" (1987).